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Jeremy  B.  Tuttle
Degree(s): Ph.D.
Graduate School: Johns Hopkins, School of Medicine
Primary Appointment: Professor of Neuroscience
Research Interests:
Neurodegenerative and Aging Dysfunction at the Cellular Level

Email Address: jbt6w@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Neuroscience
  • Molecular Medicine
  • Molecular Cell and Developmental Biology
    • Research Description

    Trophic interactions and factors are necessary for the survival and normal function of both synaptic partners in all systems, whether they are nerve-nerve or nerve-muscle. However, knowledge of the cellular regulation of synthesis of trophic factors is sparse and an understanding of their role in aging or disease is limited. One area of research involves testing the impact of commonly used anticholinergic drugs upon neurotrophin and amyloid-beta metabolism in transgenic and cellular models of Alzheimer disease. A second area of research involves the regulation of the micturition circuits and the role of neurotrophic factors in urological disease. This work is conducted with the Department of Urology and uses whole animal behavior, cell culture and electrophysiological approaches. Funding has been from the National Institutes of Health (National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Diseases and Stroke, National Institute on Aging), private foundations and by cooperative agreements with industry.

    Selected Publications
  • Lysiak JL, Yang SK, Klausner AP, Son H, Tuttle JB, Steers WD Tadalafil increases Akt and extracellular signal-regulated kinase ½ activation, and prevents apoptotic cell death in the penis following denervation. J Urol 179:779-785, 2008.
  • Klausner AP, Sharma, S, Fletcher S, Neff P, Yang S-K, Son H, Tuttle JB Steers WD Does oxybutinin alter plaques, amyloid beta peptides, and behavior in a mouse model of Alzheimer’s disease? J Urol 179: 1173-1177, 2008.
  • Boyette LB, Reardon MA, Mirelman AJ, Kirkley TD, Lysiak JJ Tuttle JB and Steers WD Fiber Optic Imaging of Cavernous Nerves In Vivo J Urol 178: 2694-2700, 2007.
  • Steers, W.D. and Tuttle, J.B. (2006) Mechanisms of Disease: the role of nerve growth factor in the pathophysiology of bladder disorders. Nature Clinical Practice Urology. 3(2):101-10, 2006.
  • PubMed Listings for this Faculty Member
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    Contact Information
      Office Address: PO Box 801392, MR-4, 5112, 
      Office Phone: +1 434-924-5634
      Fax Phone: +1 434-982-4159

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